A 30 year old female patient presented to her general practitioner with a one month history of weight loss, trembling of the hands and palpitation. Results of her biochemical tests were as follows: Serum free T4: 49.7 pmol/l (NR 10-22) Serum free T3: 20.1 pmol/l (NR 3.5-6.5) Serum TSH (thyrotrophin): <0.01 mU/l (NR 0.3-4.5) anti-TPO antibodies: 365 IU/l (NR 0-59) anti-TSH-receptor antibodies: 9.3 IU/L (NR 0-1) Case 1 questions 1. What is the biochemical diagnosis? 2. What is the underlying cause of her hyperthyroidism? Name two other important causes of hyperthyroidism. 3. Treatment is begun with the thionamide drug Carbimazole. How does Carbimazole work? 4. What are the main side effects of thionamide drugs? 5. Some patients are treated with the radioactive isotope 131I. Why is this effective therapy? 6. After treatment with radio iodine the patient complains of weight gain and tiredness. Repeat blood tests show: Free T4 4.9 pmol/l (NR 10-22) TSH 45.8 mU/l (NR 0.3-4.5) What has happened now?
[Solved]: A 30 year old female patient presented to her…
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