[Solved]: Mrs

Mrs. Linda Thompson is a 52-year-old female school administrator with a BMI of 34.2. She has a medical history of Type 2 Diabetes Mellitus, diagnosed five years ago, along with hypertension and irregular menstrual cycles. Recently, she was diagnosed with Polycystic Ovary Syndrome (PCOS). Mrs. Thompson presents with increased fatigue, weight gain despite dietary efforts, excessive facial hair growth, irregular periods, frequent urination, increased thirst, and tingling sensations in her feet. Her laboratory results reveal a fasting blood glucose level of 10.2 mmol/L and an HbA1c of 8.5%. Serum insulin and testosterone levels are (98 pmol/L) and (5 nmol/L), and her LH/FSH ratio is 3:1. Her lipid profile shows LDL (2.5 mmol/L) and HDL (0.8 mmol/L) levels. She is currently prescribed Metformin for diabetes management, Lisinopril for hypertension, and an oral contraceptive to address hormonal imbalances associated with PCOS. question 1) Explain the biochemical mechanisms of insulin resistance in Type 2 Diabetes.