[Answered]: A 68-year-old woman presents with bilateral knee…

A 68-year-old woman presents with bilateral knee pain that has gradually worsened over 3 years. She reports pain is worse at the end of the day after walking and improves with rest. Morning stiffness lasts about 10 minutes. Physical exam reveals bony enlargement of both knees, crepitus with range of motion, and mild effusion. X-rays show joint space narrowing and osteophytes. What is the MOST appropriate initial pharmacologic management? Question 21Select one: a. Scheduled acetaminophen 1000mg TID and topical diclofenac gel b. Methotrexate 15mg weekly with folic acid c. Oral prednisone 20mg daily for 2 weeks d. Intra-articular corticosteroid injections bilaterally